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BMC Medicine (2017) 15:Web page 7 ofTable two Absolute and relative danger of recurrent congenital anomaly (of any group) within the second pregnancy, by congenital anomaly group/subtype in the initially pregnancyCongenital anomaly group/subtype inside the 1st pregnancy Isolated anomalies Nervous system Neural tube defects Anencephaly Encephalocele Spina bifida Al profile, urinalysis), that have been regular except for LDH (lactate dehydrogenase Hydrocephalus Microcephaly Eye Ear-face-neck Cardiovascular Transposition of the excellent vessels Single ventricle Ventricular septal defect (VSD) Atrial septal defect (ASD) Pulmonary valve stenosis Aortic valve atresia/stenosis Hypoplastic left heart Coarctation of your aorta Respiratory Orofacial clefts Cleft lip Cleft lip and palate Cleft palate Digestive method Oesophageal atresia Hirschsprung disease Diaphragmatic hernia Abdominal wall Gastroschisis Urinary Cystic kidney disease Genital Limb Polydactyly Musculoskeletal Craniosynostosis Other individuals Cystic hygroma Syndromic anomalies Chromosomal syndromes Down syndrome Edward syndrome Estimated second pregnanciesb 5289 744 482 207 34 241 98 52 63 11 2282 116 17 966 165 198 one hundred 48 122 50 398 103 154 142 371 53 45 79 218 172 751 145 50 244 27 47 27 61 45 2072 1073 536 95 Situations 190 31 16 8 2 six five five 3 1 79 two two 38 8 four three 2 four 1 14 4 6 5 12 2 two five three three 34 eight 1 five 2 4 2 2 two 111 47 15 four 538 441 280 433 (448-645) (332-583) (169-460) (163-1099) three.25 2.63 1.66 2.57 (2.70-3.91) (1.98-3.50) (1.01-2.75) (0.98-6.72)