Internationally authorized and clinically meaningful definition, classification and inclusion criteria. The

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BMC Medicine (2017) 15:Page 7 ofTable two Absolute and relative danger of recurrent congenital anomaly (of any group) in the second pregnancy, by congenital anomaly group/subtype within the first pregnancyCongenital anomaly group/subtype in the very first pregnancy Isolated anomalies Nervous program Neural tube defects Anencephaly Encephalocele Spina bifida Hydrocephalus Microcephaly Eye Ear-face-neck Cardiovascular Transposition in the great vessels Single ventricle Ventricular septal defect (VSD) Atrial septal defect (ASD) Pulmonary valve S to correct for differences in the proportion of missing data stenosis Aortic valve atresia/stenosis Hypoplastic left heart Coarctation of your aorta Respiratory Orofacial clefts Cleft lip Cleft lip and palate Cleft palate Digestive system Oesophageal atresia Hirschsprung illness Diaphragmatic hernia Abdominal wall Gastroschisis Urinary Cystic kidney disease Genital Limb Polydactyly Musculoskeletal Craniosynostosis Other folks Cystic hygroma Syndromic anomalies Chromosomal syndromes Down syndrome Edward syndrome Estimated second pregnanciesb 5289 744 482 207 34 241 98 52 63 11 2282 116 17 966 165 198 one hundred 48 122 50 398 103 154 142 371 53 45 79 218 172 751 145 50 244 27 47 27 61 45 2072 1073 536 95 Situations 190 31 16 8 two six five five 3 1 79 two 2 38 eight four 3 2 four 1 14 4 6 five 12 2 2 5 3 three 34 eight 1 5 two four 2 two two 111 47 15 four 538 441 280 433 (448-645) (332-583) (169-460) (163-1099) three.25 2.63 1.66 2.57 (2.70-3.91) (1.98-3.50) (1.01-2.75) (0.98-6.72)